Isofetamid and spiropidion pesticide tolerances
Two final pesticide rules went into effect at the end of July 2022. The first rule set tolerances for residues of isofetamid, a broad-spectrum fungicide, in or on 141 commodities. The second rule set tolerances for residues of the insecticide spiropidion in or on 17 commodities. You could be impacted by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer.
The tolerances listed for residues of isofetamid on raw agricultural commodities had a wide range. Isofetamid in or on the commodity almond is 0.01 parts per million (ppm), while on small vine climbing fruit, except grape, it is 10.0 ppm.
Commodities besides almonds and climbing fruit include lettuce, peas, and many types of beans, just to name a few. For spiropidion, tolerances were set in or on the following:
- Cucumber and tomato at 0.8 ppm;
- Muskmelon, pumpkin, and watermelon at 0.9 ppm;
- Bell pepper, non-bell pepper, and potato at 1.5 ppm;
- Soybean seed at 3 ppm;
- Cattle, goat, horse, and sheep fat at 0.03 ppm; and
- Cattle, goat, horse, and sheep meat byproducts at 0.3 ppm.
The Environmental Protection Agency (EPA) can set a tolerance only if it is determined to be safe. This means that there is a reasonable certainty that no harm will come from aggregate exposure to the pesticide chemical residue, including all expected dietary exposures and all other exposures for which there is dependable data. EPA concludes there is a reasonable certainty that no harm will come to the overall population, or to infants and children, from aggregate exposure to isofetamid or spiropidion residues.
While EPA did make this no harm conclusion regarding exposure, it is important to note that when the toxicity data for spiropidion was reviewed, chronic dog studies showed evidence of potential neurotoxicity. Results revealed that acute and chronic exposure of spiropidion at doses equal to or greater than 30 mg/kg/day showed effects such as abnormal breathing and tremors, leading to euthanasia. EPA says there is little concern because the current point of departure (15 mg/kg/day) is much lower and protects from any possible developmental and/or reproductive effects that may happen over the higher tested doses, like what was tested in the dog studies. The point of departure is used in part to calculate safe exposure levels.
Key to remember: Pesticide tolerances were set for residues of isofetamid in or on 141 commodities and spiropidion in or on 17 commodities.