If failure to designate specific hazards in general industry may lead to accidental injury to employees or the public, or both, or to property damage, then signs or symbols are required under 29 CFR 1910.145 to indicate and, insofar as possible, to define those hazards. However, these requirements do not apply to street/highway/railroad signs, news releases, in-house safety posters, or bulletins.
Also under 1910.145, OSHA says that tags must be used as a means to prevent accidental injury or illness to general industry employees who are exposed to hazardous or potentially hazardous conditions, equipment, or operations which are out of the ordinary, unexpected, or not readily apparent. Tags must be used until such time as the identified hazard is eliminated or the hazardous operation is completed. However, tags need not be used where signs, guarding, or other positive means of protection are being used.
Other provisions under 29 CFR 1910 have further requirements for safety signs, labels, tags, and other markings. Whether they apply to you depends if you fall under the scope and applicability of the specific regulation and the marking requirement itself.