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OSHA says that it is not opposed to the use of pre-printed labels; however, the HazCom standards does not allow the use of blank red frames on labels. Blacking out the unused frame(s) is compliant with HazCom requirements because it is not a “square red frame set at a point without a hazard symbol.” However, if a blank red frame is not fully covered and filled in, the label would not be in compliance.
OSHA says that adding the words “See Adjacent Pictogram(s)” within the blacked-out area may help to reduce any potential concerns about whether a blackened frame is a defaced label.