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The Commonwealth of Massachusetts has adopted by reference the federal Hazardous Materials Regulations (HMR), Title 49, Code of Federal Regulations (CFR), Parts 171 – 180, as well as Parts 390 – 397 of the Federal Motor Carrier Safety Regulations. This adoption has been in effect since May 27, 1988, and governs both intrastate and interstate commerce on the public ways of Massachusetts. The State Fire Marshal's Office has specific regulations governing the transportation of flammable liquids (combustible liquids) by Massachusetts registered vehicles.
The Massachusetts State Police (MSP) and the State Fire Marshal's Office exercise regulatory control over the transportation of hazardous materials within the state.
The Massachusetts Department of Environmental Protection (DEP) is the lead agency in developing and administering the hazardous waste management program within Massachusetts.